Evidence map›Paper›PMID 42604006›Full record

ArticleiScience2026

The use of multi-species probiotic-derived vesicles to encapsulate luteolin for preventing colitis in a mouse model.

Shulin Hou, Haishan Yang, Qian Wang, Xin Zheng, Ruining Li, Huili He, Lei Wang, Taoran Zhao, Qizhi Shuai, Yaojun Sun and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shulin HouDepartment of Biochemistry and Molecular Biology, College of Basic Medicine, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Haishan YangDepartment of Biochemistry and Molecular Biology, College of Basic Medicine, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Qian WangDepartment of Biochemistry and Molecular Biology, College of Basic Medicine, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Xin ZhengDepartment of Biochemistry and Molecular Biology, College of Basic Medicine, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Ruining LiDepartment of Biochemistry and Molecular Biology, College of Basic Medicine, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Huili HeDepartment of Biochemistry and Molecular Biology, College of Basic Medicine, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Lei WangDepartment of Biochemistry and Molecular Biology, College of Basic Medicine, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Taoran ZhaoDepartment of Biochemistry and Molecular Biology, College of Basic Medicine, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Qizhi ShuaiDepartment of Biochemistry and Molecular Biology, College of Basic Medicine, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Yaojun SunDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Tianru JinBanting and Best Diabetes Centre and Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Zhizhen LiuDepartment of Biochemistry and Molecular Biology, College of Basic Medicine, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Jun XieDepartment of Biochemistry and Molecular Biology, College of Basic Medicine, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi 030001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotic-derived membrane vesicles (MVs) offer advantages over live probiotics, including lower immunogenicity and enhanced bioavailability of dietary compounds. However, their composition and function depend on culture conditions. In this study, MVs from a single probiotic strain (S-MVs) were compared with those from co-cultured multi-species probiotics (M-MVs). M-MVs showed superior radical scavenging ability due to characteristic antioxidant proteins. Luteolin (Lut), a hydrophobic flavonoid, was loaded into M-MVs to generate Lut-MVs. Compared with Lut or M-MVs alone, Lut-MVs had enhanced water solubility, gastrointestinal stability, and antioxidative capacity. In a dextran sulfate sodium (DSS)-induced mouse colitis model, Lut-MVs prevented colitis by alleviating oxidative damage, improving intestinal barrier function, reducing inflammatory responses, and regulating colonic microbial balance. This work provides a method for preparing probiotic-derived vesicles and highlights their potential as carriers for hydrophobic drugs in treating colon diseases.

Indexed as

anti-inflammationcolitisintestinal barrierluteolinmicrobiota regulationmulti-speciesprobiotic-derived vesicles

Identifiers

PMID42604006
PMCPMC13476518

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.