Dual-mode light/ROS-responsive microneedles enable adaptive nitric oxide therapy across tissue depths.

Yanwen Ding, Hao Han, Xiaolin Pan, Fei Li, Songfeng Chen, Hongjian Liu, Chengwei Li, Guiying Li, Lin Jin

Abstract read

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Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Yanwen DingInternational Joint Research Laboratory for Biomedical Nanomaterials of Henan, Henan Key Laboratory of Intelligent Biomaterials and Medical Applications, Zhoukou Normal University, Zhoukou, 466001, China.

Hao HanDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Xiaolin PanInternational Joint Research Laboratory for Biomedical Nanomaterials of Henan, Henan Key Laboratory of Intelligent Biomaterials and Medical Applications, Zhoukou Normal University, Zhoukou, 466001, China.

Fei LiInternational Joint Research Laboratory for Biomedical Nanomaterials of Henan, Henan Key Laboratory of Intelligent Biomaterials and Medical Applications, Zhoukou Normal University, Zhoukou, 466001, China.

Songfeng ChenDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Hongjian LiuDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Chengwei LiSchool ofAgriculture and Biomanufacturing, Zhengzhou University, Zhengzhou, 450001, China.

Guiying LiThe Key Laboratory of Basic Research on Blood Purification Application in Hebei Province, Department of Nephrology, Affiliated Hospital of Hebei Engineering University, Handan, 056002, China.

Lin JinInternational Joint Research Laboratory for Biomedical Nanomaterials of Henan, Henan Key Laboratory of Intelligent Biomaterials and Medical Applications, Zhoukou Normal University, Zhoukou, 466001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing therapeutic biomaterials capable of adapting their activation mechanisms according to tissue accessibility remains a major challenge for treating heterogeneous pathological microenvironments. Herein, we report a microenvironment-adaptive hydrogel microneedle platform (CD/MN) by integrating L-arginine-derived carbon dots into a ROS-responsive hydrogel matrix, enabling tissue-depth-dependent nitric oxide (NO) therapy through complementary activation pathways. Under external light irradiation, photo-generated singlet oxygen facilitates NO generation for rapid antibacterial therapy in superficial infected wounds. In contrast, in deep tissues where light penetration is inaccessible, endogenous pathological ROS activates hydrogel degradation, enabling sustained release of L-arg CDs and prolonged NO-mediated immunoregulatory bioactivity. The microneedle architecture further provides localized delivery and prolonged tissue retention, thereby enhancing therapeutic efficiency. Importantly, the same material platform operates through light-triggered activation in superficial infected burns and ROS-driven autonomous activation in intervertebral disc degeneration, demonstrating adaptive therapeutic behavior across tissues with distinct activation accessibility.

Indexed as

Burn wounds healingIntervertebral disc degenerationNitric oxide therapyResponsive microneedles

Identifiers

PMID42603980

DOI10.1016/j.mtbio.2026.103526

PMCPMC13476490

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.