Evidence map›Paper›PMID 42603834›Full record

ArticleAnnals of surgical oncology2026

Salvage Surgery After Proton Beam-Based Chemoradiotherapy for Esophageal Squamous Cell Carcinoma: A Case Series Study.

Hirohito Kakinuma, Michitaka Honda, Soshi Hori, Ryuya Yamamoto, Kazuki Nishino, Yoshiaki Takagawa, Nobuyasu Suzuki, Yoshinao Takano

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Hirohito KakinumaDepartment of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan. h.kakinuma.0922@gmail.com.
Michitaka HondaDepartment of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Soshi HoriDepartment of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Ryuya YamamotoDepartment of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Kazuki NishinoDepartment of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Yoshiaki TakagawaDepartment of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Nobuyasu SuzukiDepartment of Surgery, Southern Tohoku Research Institute for Neuroscience Southern Tohoku General Hospital, Fukushima, Japan.
Yoshinao TakanoDepartment of Surgery, Southern Tohoku Research Institute for Neuroscience Southern Tohoku General Hospital, Fukushima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough salvage surgery after photon-based chemoradiotherapy for esophageal squamous cell carcinoma (ESCC) is high risk, the safety of salvage surgery after proton beam-based chemoradiotherapy (PBC) remains unclear. This study aimed to evaluate the short- and long-term outcomes of salvage surgery after PBC.

methodsThis single-arm retrospective case series included patients who underwent curative-intent salvage surgery for residual or recurrent ESCC after PBC between June 2009 and February 2020. Salvage surgery included esophagectomy with lymph node dissection or resection of recurrent lymph nodes. The primary outcome was major morbidity (Clavien-Dindo grade ≥III).

resultsThe study enrolled 19 patients with a median age was 64 years. Of the 19 patients, 12 underwent esophagectomy, and 7 underwent lymph node resection. Major morbidity occurred for 9 patients (47.3%). No operative mortality occurred. The median overall survival was 16.2 months. The 1-, 3-, and 5-year overall survival rates were 68.0%, 43.1%, and 35.9%, respectively.

conclusionSalvage surgery after PBC for ESCC remains a high-risk procedure, and its feasibility should be carefully assessed on a case-by-case basis.

Indexed as

Esophageal squamous cell carcinomaProton beam-based chemoradiotherapySalvage surgery

Identifiers

PMID42603834

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