Evidence map›Paper›PMID 42603779›Full record

ArticleChemMedChem2026

Inducing Metabolic Dysfunction in Breast Cancer Cells Through Targeted Inhibition of α- and β-Glucosidase and Amylase: Novel Carbohydrate (C

Emel Karakılıç, Gökay Aydın, Gamze Güney Eskiler, Sinan Başçeken, Arif Baran

Abstract read
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emel KarakılıçDepartment of Chemistry, Science Faculty, Sakarya University, Sakarya, Turkey.ORCID https://orcid.org/0000-0002-8447-2851
Gökay AydınKaramanoglu Mehmetbey University, Vocational School of Health Services, Karaman, Turkey.ORCID https://orcid.org/0000-0002-3423-2091
Gamze Güney EskilerDepartment of Medical Biology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.ORCID https://orcid.org/0000-0002-2088-9914
Sinan BaşçekenDepartment of Chemistry, Science Faculty, Hitit University, Çorum, Turkey.ORCID https://orcid.org/0000-0002-6311-1918
Arif BaranDepartment of Chemistry, Science Faculty, Sakarya University, Sakarya, Turkey.ORCID https://orcid.org/0000-0002-4117-5099

Funding

Departments of Chemistry at Sakarya UniversityScientific and Technological Research Council of Turkey (TUBITAK) 113Z699Scientific and Technological Research Council of Turkey (TUBITAK) 115Z446Scientific and Technological Research Council of Turkey (TUBITAK) 217Z043
6 · The paper itself

Abstract

Natural products such as glucosidase inhibitors and aminoglycoside antibiotics are target agents that play an important role in the development of new drugs. A novel class of glucosidase inhibitors based on aminocyclitols was synthesized using a new method. This method involves arranging the α-, β-unsaturated structure by attacking the ammonia compound on the acetate group in the γ-position forming, to form the amide in the β-position. The method has enabled the synthesis of new types of C

Indexed as

alpha-GlucosidasesAmylasesAntineoplastic Agentsbeta-GlucosidaseBreast NeoplasmsCarbohydratesGlycoside Hydrolase InhibitorsCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorFemaleHumansIsomerismMolecular StructureStructure-Activity Relationshipalpha-GlucosidasesAmylasesAntineoplastic Agentsbeta-GlucosidaseCarbohydratesGlycoside Hydrolase Inhibitorsaminocarbasugarsaminocyclitolscell lineenzyme inhibition

Identifiers

PMID42603779
PMCPMC13477433

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.