ArticleChemMedChem2026
Novel C3-Aminated Galantamine Derivatives as Selective Butyrylcholinesterase Inhibitors With Neuroprotective Effects.
Fu-Lian Tang, Li-Jun Huang, Yan-Xu Wang, Su-Mei Wang, Wan-Sheng Ji, Feng Gao, Lian Sun, Jin-Bu Xu
Abstract read
In one paragraphArticle in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Fu-Lian TangSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P. R. China.
Li-Jun HuangSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P. R. China.
Yan-Xu WangSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P. R. China.
Su-Mei WangSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P. R. China.
Wan-Sheng JiSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P. R. China.
Feng GaoSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P. R. China.ORCID https://orcid.org/0000-0001-9436-681X Lian SunSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P. R. China.
Jin-Bu XuSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P. R. China.
Funding
Fundamental Research Funds for the Central Universities 2682026CX101National Natural Science Foundation of China 82404470Natural Science Foundation of Sichuan Province 2025ZNSFSC1731
6 · The paper itselfAbstract
To explore natural-inspired novel anti-AD bioactive molecules, a series of galantamine derivatives 6a-6u were synthesized via Pd-catalyzed Buchwald-Hartwig cross-coupling, with various nitrogen-containing functional groups installed at the C3 position of galantamine. Compared with galantamine, these compounds showed greatly enhanced selective BChE inhibition activity, suggesting that the C3 position of galantamine might be a key modifiable site for developing new selective BChE inhibitors. Among them, the derivative 6l which contained a 3,5-difluoroaniline structure moiety exhibited promising selective inhibitory activity against eqBChE, with an IC
Indexed as
ButyrylcholinesteraseCholinesterase InhibitorsGalantamineNeuroprotective AgentsApoptosisCell Line, TumorDose-Response Relationship, DrugHumansHydrogen PeroxideMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureOxidative StressStructure-Activity RelationshipButyrylcholinesteraseCholinesterase InhibitorsGalantamineHydrogen PeroxideNeuroprotective AgentsAChEAlzheimer's diseaseBChE inhibitorgalantamineneuroprotection
Identifiers
PMID42603776
PMCPMC13477430
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