ArticleChemMedChem2026
Proline-Derived N-Heterocyclic Carbene Gold(I) Complexes With Dual DNA Binding and Thioredoxin Reductase Inhibition.
Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A new family of proline-derived N-heterocyclic carbene (NHC) gold(I) complexes was synthesized and fully characterized by multinuclear NMR spectroscopy and HRMS analysis. The incorporation of a proline-based fragment into the NHC scaffold enabled the generation of both neutral and cationic Au(I) complexes with distinct electronic and steric properties. Stability studies demonstrated that the complexes remain stable under physiological-like conditions for at least 48 h. Biological evaluation against A549 lung adenocarcinoma and MDA-MB-231 triple-negative breast cancer cells revealed that the cationic complexes 3 and 4 display remarkable cytotoxic activity, with IC
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