ArticleChemMedChem2026
From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors.
Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Monoamine oxidase (MAO) catalyzes the breakdown of neurotransmitters, including serotonin, dopamine, and norepinephrine. There are two isoforms of this enzyme: MAO-A and MAO-B. MAO efficacy is widely investigated in neurodegenerative (MAO-B) and depressive (MAO-A) disorders. Upon examining the structures of known inhibitors, it becomes evident that many share an aliphatic amine structure. Furthermore, the literature suggests that compounds with naphthalene skeletons, phenolic structures, and hydrazone moieties exhibit MAO inhibitory activity. In this study, 12 N-acylhydrazone derivatives (5a-f, 6a-f) were designed using ligand-based design methods. Based on biological activity studies, the MAO-A inhibition of the compounds was calculated to be 0.073-2.54 µM, and the MAO-B inhibition was 0.064-3.147 µM. Among all compounds, the derivatives bearing a naphthalene ring (5d-f, 6d-f) exhibited MAO enzyme inhibition at levels comparable to those of the reference compounds. The compound with the highest activity, 6e, had IC
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