ArticleBrain and behavior2026
Offset Analgesia and Onset Hyperalgesia: A Comparison Between Women With Non-Suicidal Self-Injury and Healthy Women.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIndividuals who engage in non-suicidal self-injury (NSSI) exhibit reduced pain sensitivity compared to the general population. It has been argued that this hypoalgesic characteristic may be attributable to hyper-effective pain modulation. However, empirical support for this theory remains inconsistent. The aim of the study was to use a combined offset analgesia (OA) and onset hyperalgesia (OH) protocol to investigate if women with NSSI have a propensity to inhibit nociceptive signals to a higher degree (stronger OA response) and facilitate nociceptive signals to a lesser degree (weaker OH response), compared to a control group.
methodsData was collected from 76 women, 18-35 age (37 with NSSI and 39 healthy controls). The OA and OH protocol were combined with functional magnetic resonance imaging (fMRI).
resultsThe NSSI group displayed a weaker OH response, compared to the control group. This suggests that women with NSSI do not facilitate nociceptive signals to the same extent as healthy women. However, there were no significant differences between the groups regarding OA. Across all participants, we observed stronger activation in the primary sensory cortex during the OH condition, compared to the control condition.
conclusionsThe results offer partial support for the general hypothesis that women with NSSI demonstrate enhanced pain modulation. The fMRI finding requires replication.
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