ArticleChinese journal of integrative medicine2026
Compound Kushen Injection Mitigates Radiation-Induced Pulmonary Fibrosis by Restoring AT2 Cell Stemness and Alveolar Regenerative Capacity.
Article in Chinese journal of integrative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo determine whether radiation directly compromises AT2 cell stemness through oxidative and DNA damage, and to evaluate whether Compound Kushen Injection (CKI) protects AT2 cells, restores alveolar regeneration, and mitigates radiation-induced pulmonary fibrosis.
methodsMice were randomly assigned to a control, irradiated model, or CKI-treated group. CKI (4 mL·kg
resultsRadiation caused marked oxidative stress and γ H2AX-defined DNA damage in AT2 cells, accompanied by suppression of Sod1 and Parp1 and increased Il6 and Tgfb1 expression (P<0.01). These epithelial-intrinsic injuries led to reduced AT2 proliferation, impaired AT2-to-AT1 differentiation, and long-term accumulation of Krt8
conclusionsCKI preserves epithelial integrity by reducing oxidative and DNA damage, restoring AT2 stemness, and enhancing alveolar repair. These findings provide mechanistic support for CKI as a potential epithelial-directed therapeutic strategy for preventing or treating radiation-induced lung fibrosis.
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