Evidence map›Paper›PMID 42603100›Full record

ArticleExperimental physiology2026

Effect of chronic high-altitude hypoxia on retinal vascular phenotype, choroidal and retinal vasoreactivity in Peruvian highlanders.

Aymeric Paillisser, Julien Vincent Brugniaux, Florence Berquet, Jeremy De Abreu, Stephen Hogg, Emanuele Trucco, Martial Geiser, Tom Macgillivray, Aurélien Pichon, Paul Robach and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aymeric PaillisserDepartment of Ophthalmology, University Hospital of Grenoble Alpes, Grenoble Alpes University, Grenoble, France.
Julien Vincent BrugniauxINSERM, U1300, CHU Grenoble Alpes, HP2 Laboratory, Université Grenoble Alpes, Grenoble, France.ORCID https://orcid.org/0000-0001-8076-9861
Florence BerquetDepartment of Ophthalmology, University Hospital of Grenoble Alpes, Grenoble Alpes University, Grenoble, France.
Jeremy De AbreuDepartment of Ophthalmology, University Hospital of Grenoble Alpes, Grenoble Alpes University, Grenoble, France.
Stephen HoggVAMPIRE Project, Computing, School of Science and Engineering, University of Dundee, Dundee, UK.
Emanuele TruccoVAMPIRE Project, Computing, School of Science and Engineering, University of Dundee, Dundee, UK.
Martial GeiserInstitute of System Engineering, HES-SO Valais Wallis, Sion, Switzerland.
Tom MacgillivrayVAMPIRE Project, Center for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Aurélien PichonLaboratoire MOVE, STAPS, Université de Poitiers, Poitiers, France.
Paul RobachINSERM, U1300, CHU Grenoble Alpes, HP2 Laboratory, Université Grenoble Alpes, Grenoble, France.
Benoit ChampigneulleINSERM, U1300, CHU Grenoble Alpes, HP2 Laboratory, Université Grenoble Alpes, Grenoble, France.ORCID https://orcid.org/0000-0003-0922-5102
Samuel VergesINSERM, U1300, CHU Grenoble Alpes, HP2 Laboratory, Université Grenoble Alpes, Grenoble, France.ORCID https://orcid.org/0000-0002-0831-9222
Christophe ChiquetDepartment of Ophthalmology, University Hospital of Grenoble Alpes, Grenoble Alpes University, Grenoble, France.ORCID https://orcid.org/0000-0002-7601-4885

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-altitude chronic hypoxia can induce excessive erythrocytosis (EE, defined as a haemoglobin concentration of ≥21 g/dL in men), leading to hyperviscosity and promoting endothelial dysfunction. We aimed to assess whether EE affects the retinal vascular phenotype and the ophthalmological vascular response to CO

Indexed as

Altitude SicknessChoroidHypoxiaRetinaRetinal VesselsAdultAltitudeCarbon DioxideCross-Sectional StudiesFemaleHumansHypercapniaMaleMiddle AgedPeruPhenotypeCarbon Dioxidehigh altitudehypoxiaretinal vasculature

Identifiers

PMID42603100
PMCPMC13476870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.