ArticleCureus2026
Disseminated Histoplasmosis: The Great Mimicker in Patients With Advanced HIV Disease.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histoplasmosis is a systemic mycosis. In patients infected with HIV, the disseminated form represents one of the most severe presentations of the disease. While the infection primarily manifests in the pulmonary system, it can also present cutaneously or intestinally, posing a significant diagnostic challenge. We report the case of a 28-year-old male patient with a diagnosis of HIV and disseminated histoplasmosis (involving cutaneous, pulmonary, and intestinal systems). He presented with disseminated dermatosis, hepatosplenomegaly, pancytopenia, dysphagia, and subsequent gastrointestinal bleeding; skin and intestinal biopsies confirmed the diagnosis. The patient was treated with amphotericin B (sodium deoxycholate), resulting in a favorable clinical outcome. He was discharged with a subsequent regimen of oral antifungal therapy and antiretrovirals. Disseminated histoplasmosis remains a frequent opportunistic infection in patients living with HIV. Cutaneous manifestations are often nonspecific. In patients with severe immunosuppression, histoplasmosis should always be considered among the differential diagnoses.
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