Tetracycline-loaded nanomotors target neutrophil activation and oxidative stress in acute lung injury.

Saiqi Li, Ziqiang Zhang, Qianyun Zhang, Yi Shen, Chong Zhang, Jia Huang, Fan Su, Yuning Sun

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Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Saiqi LiSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China.

Ziqiang ZhangNational and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P.R. China.

Qianyun ZhangSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China.

Yi ShenSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China.

Chong ZhangSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China.

Jia HuangDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China.

Fan SuSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China.

Yuning SunDepartment of Pediatric Endocrinology and Genetic Metabolism, Xinhua Hospital, Shanghai Institute of Pediatric Research, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI) has high mortality, underscoring the urgent need for effective therapies. Excessive inflammation, mainly driven by neutrophil activation and caspase-1-mediated IL-1β/IL-18 release, along with oxidative stress, plays a pivotal role in ALI progression. Tetracycline (TH) has shown promise in suppressing caspase-1-inflammasome signaling, and its therapeutic efficacy could be further enhanced through targeted delivery. Here, we developed a nitric oxide (NO)-driven nanomotor for reactive oxygen species (ROS)-responsive TH delivery (PMA@TH), enabling precise TH delivery to inflammatory lung tissues. Upon intratracheal administration, PMA@TH migrates to injury sites with high ROS concentrations to achieve precise drug release and the generated NO further enhances tissue penetration. The nanomotor not only inhibits neutrophil infiltration but also promotes macrophage M2 polarization, mitigating both local and systemic inflammation. Transcriptomic analysis further confirmed the dual anti-inflammatory and antioxidant effects of PMA@TH. This strategy demonstrates superior therapeutic outcomes in ALI models, offering a promising nanomedicine for clinical translation.

Indexed as

acute lung injurycaspase-1 signalingnanomedicinenanomotoroxidative stress

Identifiers

PMID42602995

DOI10.1016/j.isci.2026.117106

PMCPMC13475673

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