ArticleiScience2026
Plasma metabolomic signatures of migraine in 479,760 adults.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Migraine has been linked to metabolic and vascular factors, and previous metabolomic studies have implicated HDL-related alterations, but large-scale prospective evidence remains limited. We analyzed 251 baseline plasma metabolites measured by nuclear magnetic resonance in 479,760 UK Biobank participants, including 6,724 incident hospital-diagnosed migraine cases during follow-up. Prospective and cross-sectional analyses replicated and extended a coherent lipid and lipoprotein pattern: HDL-related measures were generally inversely associated with hospital-diagnosed migraine, whereas triglyceride-rich and VLDL-related measures showed positive associations. Repeated least absolute shrinkage and selection operator (LASSO) analysis prioritized 12 metabolite features, which were further examined in exploratory analyses of brain structural imaging phenotypes, migraine polygenic risk, and affective and sleep-related traits. These findings provide large-scale prospective evidence supporting a structured plasma metabolomic profile associated with hospital-diagnosed migraine and contextualize systemic lipid and lipoprotein metabolism as a relevant domain for future mechanistic and translational studies of migraine-related metabolic variation.
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