Rapid noncontact laser speckle imaging for perfusion-based differentiation of wound necrosis.

Meng-Che Hsieh, Rou-Zheng Lai, Yan-Ren Lin, Ching-Han Hsu, Pei-You Hsieh, Wei-Fan Chen, Congo Tak Shing Ching, Lun-De Liao

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Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Meng-Che HsiehInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan.

Rou-Zheng LaiInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan.

Yan-Ren LinDepartment of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.

Ching-Han HsuDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, No. 101, Section 2 Kuang-Fu Road, Hsinchu 30013, Taiwan.

Pei-You HsiehDepartment of Emergency and Critical Care Medicine, Changhua Christian Hospital, Changhua, Taiwan.

Wei-Fan ChenInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan.

Congo Tak Shing ChingDoctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, 145 Xingda Road, South District, Taichung 402, Taiwan.

Lun-De LiaoInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional wound assessment relies on subjective visual inspection, which may miss early microvascular changes. In this study, laser speckle contrast imaging (LSCI) was used to differentiate necrotic from nonnecrotic wounds using quantitative perfusion under a shortened protocol. Forty wound patients (20 acute, 15 chronic, and 5 necrotic) and 20 participants without wound lesions were included. Within-subject normalized perfusion (percent change relative to adjacent healthy skin) served as the predictor. Significant differences were observed among wound types (

Indexed as

blood perfusionchronic woundlaser speckle contrast imagingwound healing prediction

Identifiers

PMID42602961

DOI10.1016/j.isci.2026.117032

PMCPMC13475678

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.