Evidence map›Paper›PMID 42602959›Full record

ArticleBiochemistry and biophysics reports2026

Lipidomic analysis of A1, A2, and heterozygous beta-casein genotypes in bovine milk using gas chromatography-mass spectrometry.

Phelipe A B M Peres, Milton J Filho, Hebreia O A Souza, Mário M Martins, Arlene B S Nossol, Douglas C Caixeta, Arthur F Demétrio, Thais F M Reis, Natieli Saito, Ana Graci Brito-Madurro and 2 more

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Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Phelipe A B M PeresLaboratory of Nanobiotechnology, Professor Dr. Luiz Ricardo Goulart Filho, Universidade Federal de Uberlândia, Campus Umuarama, Uberlândia, MG, 38492-045, Brazil.
Milton J FilhoDepartment of Pharmacy, Institute of Life Sciences, Federal University of Juiz de Fora, Governador Valadares, MG, 35032-620, Brazil.
Hebreia O A SouzaLaboratory of Nanobiotechnology, Professor Dr. Luiz Ricardo Goulart Filho, Universidade Federal de Uberlândia, Campus Umuarama, Uberlândia, MG, 38492-045, Brazil.
Mário M MartinsLaboratory of Nanobiotechnology, Professor Dr. Luiz Ricardo Goulart Filho, Universidade Federal de Uberlândia, Campus Umuarama, Uberlândia, MG, 38492-045, Brazil.
Arlene B S NossolLaboratory of Nanobiotechnology, Professor Dr. Luiz Ricardo Goulart Filho, Universidade Federal de Uberlândia, Campus Umuarama, Uberlândia, MG, 38492-045, Brazil.
Douglas C CaixetaLaboratory of Nanobiotechnology, Professor Dr. Luiz Ricardo Goulart Filho, Universidade Federal de Uberlândia, Campus Umuarama, Uberlândia, MG, 38492-045, Brazil.
Arthur F DemétrioLaboratory of Nanobiotechnology, Professor Dr. Luiz Ricardo Goulart Filho, Universidade Federal de Uberlândia, Campus Umuarama, Uberlândia, MG, 38492-045, Brazil.
Thais F M ReisFaculty of Veterinary Medicine, Universidade Federal de Uberlândia, Campus Umuarama, Uberlândia, MG, 38405-240, Brazil.
Natieli SaitoLaboratory of Nanobiotechnology, Professor Dr. Luiz Ricardo Goulart Filho, Universidade Federal de Uberlândia, Campus Umuarama, Uberlândia, MG, 38492-045, Brazil.
Ana Graci Brito-MadurroBiotechnology Institute, Universidade Federal de Uberlândia, Campus Umuarama, Uberlândia, 38402-018, Brazil.
João Marcos MaduroInstitute of Chemistry, Universidade Federal de Uberlândia, Campus Santa Mônica, Uberlândia, 38408-100, Brazil.
Vivian Alonso-GoulartLaboratory of Nanobiotechnology, Professor Dr. Luiz Ricardo Goulart Filho, Universidade Federal de Uberlândia, Campus Umuarama, Uberlândia, MG, 38492-045, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The consumption of A2 milk, which contains only the A2 type of beta-casein, has been increasing because it is considered healthier. In contrast, milk that contains the A1 type of beta-casein may cause gastrointestinal discomfort due to the release of the peptide beta-casomorphin-7 during digestion. The milk is composed of valuable proteins, liposoluble vitamins, and mineral salts, that could be essential source of dietary lipids for humans. The lipidomic analysis allows the characterization of important milk lipids. In this context, the objective of this work was to describe and determine the lipid profile and differential compounds in genotypes A1A1, A2A2, and A1A2 for beta-casein from bovine milk. Lipid extraction followed by gas chromatography coupled with mass spectrometry were performed on 54 bovine milk samples. As results, 12 differential metabolites were found, where the cholesterol; Cholesta-3,5-diene and Cholest-5-ene-3-ol(3. beta.)-carbonochloridate were the most abundant lipid compound in A2 milk. The identified lipids participate of the important pathways, such as the fatty acyl. The data obtained in this exploratory study provide insights into the main differences between the lipidomic profile of bovine milk present different beta-caseins in its composition.

Indexed as

Beta caseinBovineLipidesMilk A2

Identifiers

PMID42602959
PMCPMC13475644

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