ArticlePeerJ2026
Investigation and validation of prognostic features associated with transient receptor potential channel genes in gastric cancer.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Background: An increasing body of evidence suggests an association between transient receptor potential (TRP) channel s and cancer development; however, a systematic evaluation of the combined prognostic value of TRP channel-related genes (TRGs) in gastric cancer (GC) has not been conducted. Methods: Data were obtained from The Cancer Genome Atlas Stomach Adenocarcinoma, GSE84433, and TRGs. Prognostic genes related to TRP channels and GC were screened, and a risk model was constructed. Functional analysis, immune correlation analysis, and molecular regulatory network construction were performed to identify mechanisms associated with GC prognosis. Finally, the expression of prognostic genes was preliminarily assessed in clinical samples using reverse transcription quantitative polymerase chain reaction (RT-qPCR) for exploratory validation. Results: Seven genes associated with GC prognosis (5-hydroxytryptamine 2C receptor ( Conclusions: Seven prognostic genes (
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