Evidence map›Paper›PMID 42602773›Full record

ArticleAnimal nutrition (Zhongguo xu mu shou yi xue hui)2026

Mechanically activated zinc oxide enhances growth performance and protects against diarrhea with potentially regulating gut microbiota in weaned piglets.

Zhijie Yuan, Jingqi Huang, Jinxin Guo, Bingbing Zhang, Weicheng Bei, Yong Wang, Yong Li, Hairui Xin, Weigang Xing, Yakuan Huang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhijie YuanNational Key Laboratory of Agricultural Microbiology, Key Laboratory of Smart Farming Technology for Agricultural Animals of Ministry of Agriculture and Rural Affairs, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Jingqi HuangNational Key Laboratory of Agricultural Microbiology, Key Laboratory of Smart Farming Technology for Agricultural Animals of Ministry of Agriculture and Rural Affairs, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Jinxin GuoNational Key Laboratory of Agricultural Microbiology, Key Laboratory of Smart Farming Technology for Agricultural Animals of Ministry of Agriculture and Rural Affairs, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Bingbing ZhangNational Key Laboratory of Agricultural Microbiology, Key Laboratory of Smart Farming Technology for Agricultural Animals of Ministry of Agriculture and Rural Affairs, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Weicheng BeiThe Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Yong WangYishi Biotechnology Co., Ltd., Shanghai 201700, China.
Yong LiCOFCO Feed Co., Ltd., Beijing 100102, China.
Hairui XinNewhope Liuhe Co., Ltd., Beijing 100102, China.
Weigang XingNewhope Liuhe Co., Ltd., Beijing 100102, China.
Yakuan HuangNewhope Liuhe Co., Ltd., Beijing 100102, China.
Lvhui SunNational Key Laboratory of Agricultural Microbiology, Key Laboratory of Smart Farming Technology for Agricultural Animals of Ministry of Agriculture and Rural Affairs, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Zhangchao DengNational Key Laboratory of Agricultural Microbiology, Key Laboratory of Smart Farming Technology for Agricultural Animals of Ministry of Agriculture and Rural Affairs, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High pharmacological doses of zinc oxide (ZnO) are widely used to control post-weaning diarrhea, but environmental pollution and potential adverse effects necessitate the search for effective low-dose alternatives. This study aimed to investigate the effects of dietary level of mechanically activated zinc oxide on growth performance and diarrhea in weaned piglets. A total of 1152 healthy weaned piglets (6.72 ± 0.63 kg) at 21 d of age were randomly assigned to six treatment groups with six replicates of 32 pigs per pen. Piglets received either a basal diet (BD), the BD supplemented with 100, 200, 400, or 600 mg Zn/kg mechanically activated zinc oxide (100 Zn, 200 Zn, 400 Zn, and 600 Zn), or the BD supplemented with 1600 mg Zn/kg conventional ZnO (1600 Zn) over a 28-d feeding period. Compared with the BD group, dietary 400 Zn supplementation significantly increased average daily gain during d 1 to 14, and decreased the feed/gain ratio during d 1 to 14 and d 1 to 28 (

Indexed as

Gut microbiotaIntestinal healthMetabolomicTryptophan metabolismWeaned pigletZinc oxide

Identifiers

PMID42602773
PMCPMC13474652

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.