ArticlePlastic and reconstructive surgery. Global open2026
Enhancing Regenerative Outcomes: Histological Comparison of Hydroxyapatite-Carboxymethylcellulose Combined With Saline vs Platelet-rich Fibrin: A 21-day Study.
Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Enhancing Regenerative Outcomes: Histopathological Comparison of Calcium Hydroxylapatite Alone and Combined With Platelet-rich Fibrin: A 6-week Study.Plastic and reconstructive surgery. Global open · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Calcium hydroxyapatite-carboxymethylcellulose (CaHA-CMC) is a widely used biostimulatory agent that promotes collagen production and tissue remodeling. Platelet-rich fibrin (PRF), rich in growth factors, may enhance this biological response. This study evaluates the subdermal histopathological changes induced by saline solution (SS), PRF, CaHA-CMC + SS, and CaHA-CMC + PRF, with emphasis on early extracellular matrix remodeling and cellular response. Methods: A prospective study was conducted in 5 patients undergoing subdermal injections of the 4 study groups. Tissue samples were obtained at 21 days postinjection. Hematoxylin and eosin staining was analyzed using a semiquantitative digital histomorphometric surrogate (collagen-associated eosinophilic area). Immunohistochemical analysis for CD45 and collagen (types I, III, and IV) was performed in CaHA-containing groups. Statistical comparisons were conducted using the Wilcoxon signed-rank test. Results: CaHA-CMC + PRF demonstrated a significantly higher collagen-associated eosinophilic area compared to the saline control (3.07 times more; 95% CI: 2.10-4.20; Conclusions: The addition of PRF to CaHA-CMC appears to potentiate early subdermal tissue remodeling and cellular response. These findings suggest a synergistic biological effect; however, larger studies are required to confirm long-term clinical implications.
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Registered trials
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