Evidence map›Paper›PMID 42602702›Full record

ArticleiScience2026

Pathophysiological and translational implications of the dysregulation of molecular machineries controlling RNA metabolism in thyrotropinomas.

Miguel E G-García, Álvaro Flores-Martínez, Laura Arroyo-Millán, Eva Venegas, Cristina M Diaz-Perdigones, Silvia Maraver, David Cano, Cinta Arráez, Miguel A Arráez, Miguel A Japón and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Miguel E G-GarcíaDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain.
Álvaro Flores-MartínezDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain.
Laura Arroyo-MillánDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain.
Eva VenegasUnidad de Gestión de Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Cristina M Diaz-PerdigonesEndocrinology and Nutrition Service, Virgen de La Victoria University Hospital, Málaga, Spain.
Silvia MaraverEndocrinology and Nutrition Service, Virgen de La Victoria University Hospital, Málaga, Spain.
David CanoUnidad de Gestión de Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Cinta ArráezNeurosurgery Department, Regional University Hospital, Málaga, Spain.
Miguel A ArráezNeurosurgery Department, Regional University Hospital, Málaga, Spain.
Miguel A JapónDepartment of Pathology, Hospital Universitario Virgen Del Rocío, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain.
Antonio J Martínez-FuentesDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain.
Alfonso Soto-MorenoUnidad de Gestión de Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Antonio C Fuentes-FayosDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain.
Aura D Herrera-MartínezMaimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Córdoba, Spain.
Raúl M LuqueDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The contribution of post-transcriptional regulation remains largely unexplored in thyrotropin-secreting pituitary tumors (TSHomas), a rare endocrine pathology responsible for inappropriate TSH secretion and central hyperthyroidism. We investigated the TSHoma post-transcriptional regulatory landscape by analyzing components of molecular machineries controlling RNA metabolism [spliceosome/RNA-exosome/nonsense-mediated decay (NMD)], their associations with clinical parameters, and the impact of their pharmacological inhibition in TSHoma cells. A drastic dysregulation of multiple components of spliceosome [spliceosome (

Indexed as

cell cultureNMDprognosisRNA-exosomesplicingTSHomas

Identifiers

PMID42602702
PMCPMC13475698

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.