ArticleACS polymers Au2026
Dynamic Arrest and Tunable Gelation of Immunogenically Inert POEGMA Nanoparticles.
Article in ACS polymers Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Physically cross-linked hydrogels formed through noncovalent interactions offer reversible gelation, injectability, and shear-thinning behavior, making them ideal for biomedical applications. Temperature-responsive systems are particularly attractive, as they enable injection as a solution, and at physiological temperature for minimally invasive delivery. Poly-(oligo-(ethylene glycol) methacrylate) (POEGMA) is a promising nonimmunogenic polymer that combines PEG-like hydration and protein resistance with tunable thermal responsiveness that does not bind pre-existing anti-PEG antibodies that are ubiquitous and elicits a minimal antibody response against itself. Here, we show that diblock POEGMA copolymerscomposed solely of short ethylene glycol side chainsspontaneously self-assemble into nanoparticles and form physically cross-linked hydrogels above a controllable transition temperature, without chemical modification. Using fluorescence recovery after photobleaching and video particle tracking nanorheology, we identify a thermally induced transition from dynamically arrested viscoelastic hydrogels to dynamically arrested liquid coacervates. These results establish a new class of single-component, nonimmunogenic POEGMA hydrogels with tunable phase behavior and mechanical properties, offering a versatile platform for localized drug delivery, sustained release, and regenerative medicine.
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