Observational studyJournal of medicine and life2026
Long-term health-related quality of life following an online rehabilitation program after total laryngectomy: a 3-year retrospective longitudinal study.
Observational study in Journal of medicine and life, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
This study aimed to evaluate health-related quality of life (HRQoL) trajectories after participation in an online rehabilitation course. A retrospective observational longitudinal study was conducted in accordance with the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines. We analyzed 48 patients who completed a multimodal online rehabilitation course in 2022. The curriculum covered anatomical foundations and practical techniques for voice production, deglutition, respiration, and olfactory recovery. HRQoL was assessed using the EORTC QLQ-C30 instrument at baseline (T0) and annually for 3 years (T1, T2, T3). All scores were linearly transformed to a 0-100 scale. Five patients were censored due to mortality during follow-up. Longitudinal exploratory analyses were performed using repeated-measures comparisons where appropriate. Among the 43 survivors at 3 years, clinically relevant longitudinal improvements were observed in global health status/QoL (from 58.4 ± 18.2 to 85.7 ± 9.8, +27.3 points), physical functioning (+20.9 points), role functioning (+22.5 points), and social functioning (+19.5 points). Symptom burden decreased markedly, particularly fatigue (-22.5 points), dyspnea (-22.7 points), and pain (-17.3 points). Patients with TEVP (tracheoesophageal voice prosthesis) complications (
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