Evidence map›Paper›PMID 42602538›Full record

ArticleMeasurement science & technology2020

A piezoelectric bone fixation plate for

Bradley D Nelson, Salil Sidharthan Karipott, Robert E Guldberg, Keat Ghee Ong

Abstract read
In one paragraph

Article in Measurement science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bradley D NelsonKnight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, United States of America.ORCID 0000-0001-9768-7344
Salil Sidharthan KaripottKnight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, United States of America.ORCID 0000-0002-5286-6047
Robert E GuldbergKnight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, United States of America.ORCID 0000-0002-0303-261X
Keat Ghee OngKnight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, United States of America.ORCID 0000-0003-2058-1028

Funding

Regenerative Rehabilitation of Complex Musculoskeletal InjuriesR01AR069297 · NIAMS · UNIVERSITY OF OREGON · PI ROBERT E Guldberg · 2016 to 2026
$5.6M
Mechanically Active Magnetoelastic System for Controlled Loading Environment to Promote Vascularized Bone RegenerationR15EB023648 · NIBIB · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI ONG, KEAT GHEE · 2017 to 2017
$468k
NIAMS NIH HHS R01 AR069297NIBIB NIH HHS R15 EB023648
6 · The paper itself

Abstract

Fracture non-union, the failure of a bone fracture to bridge, occurs in roughly 5%-10% of treated fractures and requires lengthy and expensive follow-up interventions. A significant body of research has investigated the efficacy of low-magnitude, high-frequency (LMHF) vibration as a treatment for femoral non-unions through the use of whole-body vibration. This work presents a novel piezoelectric fixation plate for investigating the efficacy of LMHF treatment by applying loads directly to the fracture site, thus reducing undesired systemic effects such as hormonal up-regulation induced by whole-body vibration. The fixation plate can apply mechanical loading in the LMHF regime and monitor the mechanical environment at the fracture site during ambulation to quantify progressive changes in callus stiffness over time as an indication of healing. Mechanical testing demonstrated the ability of the plate to provide displacements of up to 10 μm, as well as to estimate the changing stiffness of the fracture environment.

Indexed as

bone fracture healingfemoral non-unionlow-magnitude high-frequencypiezoelectricregenerative medicine

Identifiers

PMID42602538
PMCPMC13475034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.