ArticleiScience2026
Insights into the activity, production, and signaling circuits of homoserine lactones in mammalian cells.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Emerging evidence suggests that acyl homoserine lactones (AHLs), bacterial signaling metabolites, also play signaling roles in eukaryotic organisms, including human cells. Through a meta-analysis of prior investigations, we mapped the effects of AHLs and their signaling roles. Given their evolutionary significance and potential physiological roles, we further asked whether human cells possess the machinery to perceive and produce AHLs or similar compounds. AHLs commonly regulate pathways involved in cell-fate decisions, with RXRs and peroxisome proliferator-activated receptors (PPARs) identified as potential upstream AHL receptors. Structural specificity was supported by the observation that both the γ-butyrolactone ring and the acyl tail contribute to receptor affinity. Furthermore, human glycine/glutamine acyltransferases showed structural and functional homology to bacterial AHL synthases using
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