ArticleResearch and practice in thrombosis and haemostasis2026
Selective preservation of shear-dependent platelet adhesion during microvolume storage in a compact agitation system.
Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Platelet-based applications relying on fresh samples create logistical constraints in research workflows. While the platelet storage lesion (PSL) is well described, its impact on biomechanical platelet function remains unclear, and existing systems are poorly suited to lab-based assays. The digital storage device (DSD) is a compact device designed for room temperature (20-24 °C) microvolume (600 μL) platelet storage under gentle, oscillatory agitation. Objectives: To assess the capacity for the DSD to preserve platelet biomechanical (shear-dependent) and biochemical functions. Methods: Platelet-rich plasma (PRP) and washed platelets (WP) were stored for up to 7 days in the DSD or statically at 2 to 6 °C. Shear-dependent platelet adhesion to von Willebrand factor was assessed using a microfluidic model. Biochemical responses were evaluated by TRAP-6-induced PAC-1 activation and ADP-induced aggregation. PSL markers were also measured. Results: Shear-driven adhesion was maintained for 3 days in the DSD (WP: 93% of baseline at day 2, 97% day 3; PRP: 83% day 2, and 74% day 3) and remained GPIb-dependent. Biochemical responsiveness declined, particularly in PRP, where TRAP-6 responses decreased from 52% to 12% after 2 days and ADP aggregation from 60% to 20%. WP retained 84% to 89% TRAP-6 responsiveness over 7 days under microscopy. PSL markers increased alongside progressive glucose consumption. Conclusion: The DSD supports shear-dependent platelet adhesion for 3 days of storage in both PRP and WP. In contrast, biochemical responsiveness is not maintained. This divergence highlights that distinct platelet functions are differentially affected during storage, enabling targeted interrogation of biomechanical functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.