Evidence map›Paper›PMID 42602478›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Next-generation DNA methylation sequencing: loci and regions differentially methylated in adolescents with chronic postsurgical pain.

Siva Athitya Lakshamana Vijayarajan, Kristen N Krolick, Xue Zhang, Lisa J Martin, Susan Glynn, Kristi Cole, Victor Garcia, Hong Ji, R J Ramamurthi, L M Einhorn and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Siva Athitya Lakshamana VijayarajanDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Kristen N KrolickDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Xue ZhangDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Lisa J MartinDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Susan GlynnDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Kristi ColeDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Victor GarciaDivision of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Hong JiDepartment of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine; Cardiorespiratory Disease Unit, California National Primate Research Center, University of California, Davis, CA 95616, USA.
R J RamamurthiDepartment of Anesthesia, Lucile Packard Hospital, Palo Alto, CA 94304, USA.
L M EinhornDepartment of Anesthesia, Duke University, Durham, NC 27708, USA.
C L MonittoDepartment of Anesthesia, John Hopkins Children's Center, Baltimore, MD 21287, USA.
A GaneshDeparment of Anesthesia, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Vidya ChidambaranDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Funding

Epigenetic Determinants Influencing Development and Evolution of Chronic Post-surgical Pain in Children Undergoing Musculoskeletal Surgery.R01AR075857 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI CHIDAMBARAN, VIDYA · 2019 to 2023
$3.0M
NIAMS NIH HHS R01 AR075857
6 · The paper itself

Abstract

DNA methylation (DNAm) may link environmental exposures to pain susceptibility. We examined preoperative DNAm patterns (using next-generation enzymatic-methylation sequencing) associated with chronic postsurgical pain (CPSP), a major biopsychosocial problem in adolescents undergoing musculoskeletal surgeries, recruited across six sites (

Identifiers

PMID42602478
PMCPMC13474685

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.