Evidence map›Paper›PMID 42602457›Full record

ReviewFrontiers in immunology2026

Immune mechanism of IgA vasculitis with nephritis: a narrative review.

Chan Xiu, Jun Zhang, Baozhao Ju, Tao Ma, Jing Lv

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chan XiuAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Jun ZhangAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Baozhao JuLiaoning University of Traditional Chinese Medicine, Shenyang, China.
Tao MaShenyang Orthopedic Hospital, Shenyang, China.
Jing LvAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IgA vasculitis with nephritis (IgAVN), also known as Henoch-Schönlein purpura nephritis (HSPN) is a kidney disease secondary to IgA vasculitis (IgAV). While most pediatric IgAVN patients have a favorable prognosis, a minority may develop renal insufficiency or even progress to end-stage renal disease, compromising quality of life and imposing a significant burden on families. The etiology of IgAVN is complex, involving intricate immune system dysregulation. Elucidating its pathogenesis is crucial for guiding treatment and improving patient outcomes. Therefore, this review comprehensively synthesizes the immunopathogenic mechanisms of IgAVN including humoral, cellular, and cytokine networks to provide a robust theoretical framework for the rational design of novel therapeutic agents.

Indexed as

IgA VasculitisImmunoglobulin ANephritisAnimalsCytokinesHumansImmunity, CellularImmunity, HumoralCytokinesImmunoglobulin Acellular immunitycytokineshumoral immunityIgA vasculitisIgA vasculitis with nephritisimmune mechanism

Identifiers

PMID42602457
PMCPMC13473916

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.