Evidence map›Paper›PMID 42602446›Full record

ArticleKidney international reports2026

Randomized Controlled Trial of Integrated Kidney Supportive Care in End-Stage Kidney Disease.

Bharathi Naik, Shankar Prasad Nagaraju, Anuja Damani, Arun Ghoshal, Pankaj Singhai, Naveen Salins, Ravindra Prabhu Attur, Swathi Nayak Ammunje, Ajith M Nayak, Mohan V Bhojaraja and 3 more

Abstract read
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In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bharathi NaikDepartment of Renal Replacement Therapy and Dialysis Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India.
Shankar Prasad NagarajuDepartment of Nephrology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Anuja DamaniDepartment of Palliative Medicine and Supportive Care, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Arun GhoshalDepartment of Palliative Medicine and Supportive Care, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Pankaj SinghaiDepartment of Palliative Medicine, Sri Aurobindo Medical College and PG Institute, Sri Aurobindo University, Indore, Madhya Pradesh, India.
Naveen SalinsDepartment of Palliative Medicine and Supportive Care, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Ravindra Prabhu AtturDepartment of Nephrology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Swathi Nayak AmmunjeDepartment of Nephrology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Ajith M NayakDepartment of Renal Replacement Therapy and Dialysis Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India.
Mohan V BhojarajaDepartment of Nephrology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Srinivas Vinayak ShenoyDepartment of Nephrology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Dharshan RangaswamyDepartment of Nephrology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Indu Ramachandra RaoDepartment of Nephrology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Kidney failure is linked to a substantial symptom burden and diminished quality of life (QoL). The incorporation of kidney supportive care (KSC) and advance care planning (ACP) into routine nephrology practices could enhance patient-centered outcomes; however, data from developing countries are scarce. This study evaluated the effects of KSC versus standard care on QoL, symptom burden, and ACP engagement in kidney failure. Methods: This randomized controlled trial was conducted at a tertiary care hospital in India from June 2023 to June 2025. Adult patients with kidney failure were randomized using block randomization to receive either integrated KSC or conventional care. Outcomes, including QoL, symptom burden, and ACP engagement, were assessed at baseline and at 2, 4, and 6 months using the Edmonton Symptom Assessment System-revised (ESAS-r) Renal tool, EuroQol 5-Dimensions, 5-Levels (EQ-5D-5L), and an ACP questionnaire. Results: Patients in the intervention group showed significant improvements across multiple domains, with QoL scores increasing markedly ( Conclusion: Integrated KSC improves QoL, reduces symptom burden, and enhances ACP engagement. These findings support integrating structured KSC into routine kidney care in developing settings.

Indexed as

advance care planningkidney failurekidney supportive carenoncommunicable diseasesquality of lifesymptom burden

Identifiers

PMID42602446
PMCPMC13474389

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.