Gallate-oriented surface engineering of lignin nanoparticles for enhanced antibacterial activity.

Zonghong Lu, Shujun Liang, Depeendra Yadav, Hao Zhang, Jessica M Rosenholm, Chunlin Xu, Tapani Viitala, Xiaoju Wang

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Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Zonghong LuLaboratory of Natural Materials Technology, Department of Engineering and Information Technology, Åbo Akademi University, Henrikinkatu 2, Turku, FI-20500, Finland.

Shujun LiangLaboratory of Natural Materials Technology, Department of Engineering and Information Technology, Åbo Akademi University, Henrikinkatu 2, Turku, FI-20500, Finland.

Depeendra YadavPharmaceutical Sciences Laboratory, Department of Natural and Health Sciences, Åbo Akademi University, Tykistökatu 6A, Turku, FI-20520, Finland.

Hao ZhangLaboratory of Natural Materials Technology, Department of Engineering and Information Technology, Åbo Akademi University, Henrikinkatu 2, Turku, FI-20500, Finland.

Jessica M RosenholmPharmaceutical Sciences Laboratory, Department of Natural and Health Sciences, Åbo Akademi University, Tykistökatu 6A, Turku, FI-20520, Finland.

Chunlin XuLaboratory of Natural Materials Technology, Department of Engineering and Information Technology, Åbo Akademi University, Henrikinkatu 2, Turku, FI-20500, Finland.

Tapani ViitalaPharmaceutical Sciences Laboratory, Department of Natural and Health Sciences, Åbo Akademi University, Tykistökatu 6A, Turku, FI-20520, Finland.

Xiaoju WangLaboratory of Natural Materials Technology, Department of Engineering and Information Technology, Åbo Akademi University, Henrikinkatu 2, Turku, FI-20500, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In combating bacterial infections, antibacterial nanomaterials offer a non-pharmacological alternative to conventional antibiotics. Biomass-derived lignin exhibits intrinsic antibacterial activity from polyphenolic motifs and can readily self-assemble into nanostructures due to its amphiphilicity. However, the formation of lignin nanoparticles (LigNPs) is governed by a delicate balance of noncovalent interactions, making assembly outcomes highly dependent on lignin source and fractionation process and thereby limiting precise control over the surface chemistry and functional-group presentation. Here we have developed a gallate-oriented surface engineering strategy that combines boronated lignin nanoparticles (BLigNPs) core with gallate derivatives (GDs) corona, enabling tunable surface chemistry and modulating their bactericidal activity to preferentially target Gram-negative or Gram-positive bacteria. Through spatially grafting redox-active pyrogallol moieties in a tannic acid (TA) corona, BLigNP-TA exhibited the highest antibacterial activity against

Indexed as

Amphiphilic balanceAntibacterial activityBiocompatibilityGallate esterLignin nanoparticleSurface chemistry

Identifiers

PMID42602429

DOI10.1016/j.mtbio.2026.103517

PMCPMC13473958

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.