ArticleJHLT open2026
Phenotyping immune sensitization reveals pattern-based association with post-lung transplant complications.
Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Immune sensitization is an important contributor to adverse outcomes after lung transplantation, including impaired pulmonary function, increased risk of chronic lung allograft dysfunction (CLAD), and reduced survival. Prior studies have examined individual immunologic features, such as panel reactive antibodies (PRA), donor-specific antibodies (DSA), acute cellular rejection (ACR), and antibody-mediated rejection (AMR). However, existing literature has evaluated each of these in isolation, creating a gap in understanding regarding the potential for synergistic and overlapping effects. In this retrospective cohort study, we developed 5 immune sensitization phenotypes based on perioperative patterns of immune injury observed before and after transplantation: non-sensitized, pre-transplant humoral sensitization, post-transplant humoral sensitization, cellular-mediated sensitization, and mixed sensitization. A total of 502 adult lung transplant recipients were classified into these phenotypes and compared with respect to initial post-transplant FEV
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