Evidence map›Paper›PMID 42602410›Full record

ArticleACS polymers Au2026

Molecular Design of Thermoresponsive Poly(oligoethylene glycol)vinyl Esters for the Generation of Polymer Brush-Based Biointerfaces.

Francesco M Ara, Rachele Foladore, Alessandro Magro, Nicola Scapin, Daniele Rizzi, Alessandro Bertolo, Francesca Lorandi, Edmondo M Benetti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS polymers Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesco M AraLaboratory for Macromolecular and Organic Chemistry (MOC), Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.ORCID https://orcid.org/0009-0005-9593-4176
Rachele FoladoreLaboratory for Macromolecular and Organic Chemistry (MOC), Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.ORCID https://orcid.org/0009-0000-9045-3393
Alessandro MagroLaboratory for Macromolecular and Organic Chemistry (MOC), Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
Nicola ScapinLaboratory for Macromolecular and Organic Chemistry (MOC), Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
Daniele RizziLaboratory for Macromolecular and Organic Chemistry (MOC), Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.ORCID https://orcid.org/0009-0000-5827-8142
Alessandro BertoloLaboratory for Macromolecular and Organic Chemistry (MOC), Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
Francesca LorandiLaboratory for Macromolecular and Organic Chemistry (MOC), Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.ORCID https://orcid.org/0000-0001-5253-8468
Edmondo M BenettiLaboratory for Macromolecular and Organic Chemistry (MOC), Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.ORCID https://orcid.org/0000-0002-5657-5714

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vinyl polymers bearing oligoethylene glycol (OEG) side chains have emerged as starting materials for the generation of biointerfaces and thermoresponsive systems. Here, we report the molecular design of thermoresponsive poly-(oligoethylene glycol)-vinyl esters (POEGVEs) and evaluate their behavior in solution as well as their performance as surface-grafted polymer brushes. POEGVEs bearing one and two ethylene glycol units were synthesized via RAFT/MADIX polymerization and directly compared to the corresponding polyacrylate analogues. Despite their closely related compositions, POEGVEs exhibited markedly higher LCST values in water, indicating stronger polymer-water interactions associated with the higher polarity of the vinyl ester backbone. When assembled as polymer brush layers on model Au surfaces, POEGVEs displayed enhanced hydration, higher swelling ratios, and lower water contact angles relative to those of the corresponding poly-(oligoethylene glycol)-acrylate (POEGA) brushes. This increased hydration translated into significantly improved resistance to nonspecific protein adsorption from full human serum (FHS). Collectively, these findings identify OEG-functional poly-(vinyl ester)-s as a promising and previously overlooked platform for the design of thermoresponsive and antifouling polymer biointerfaces.

Indexed as

controlled radical polymerizationpoly(ethylene glycol)polymer brushespoly(vinyl ester)sthermoresponsive polymers

Identifiers

PMID42602410
PMCPMC13474339

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.