SynthesisJournal of medicine and life2026
Efficacy and safety of microneedling with tranexamic acid versus microneedling with vitamin C in the treatment of melasma: a systematic review and meta-analysis.
Synthesis in Journal of medicine and life, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
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Abstract
This study aimed to compare the efficacy and short-term tolerability of microneedling combined with either tranexamic acid or vitamin C for melasma. A systematic review and meta-analysis following PRISMA 2020 guidelines was conducted across five databases (MEDLINE, Google Scholar, EBSCO, ProQuest, Web of Science) and ClinicalTrials.gov (2015-2025). Eight studies (232 patients) were synthesized using a random-effects model; outcomes were harmonized across MASI, mMASI, and hemi-MASI using Hedges' g calculated from within-group change-from-baseline scores, with an imputed within-person correlation (r = 0.5; sensitivity range 0.25-0.75) for split-face designs. The pooled analysis showed no statistically significant difference between tranexamic acid and vitamin C (Hedges' g = -0.123; 95% CI, -0.311 to 0.065;
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