Evidence map›Paper›PMID 42602385›Full record

ArticleFrontiers in immunology2026

Linoleoyl-lysophosphatidylcholine drives non-inflammatory apoptosis in neutrophils via lipid rafts.

Priyanka Saminathan, Alicia Gibbons, Ian T Mathews, Maija Corey, Ashmitaa Logandha Ramamoorthy Premlal, Mahati Rayadurgam, Namratha Nadig, Camille Fang, Neha Reddy, Mousa Vatanmakanian and 2 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Priyanka Saminathan *Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Alicia Gibbons *Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Ian T MathewsCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Maija CoreyCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Ashmitaa Logandha Ramamoorthy PremlalCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Mahati RayadurgamCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Namratha NadigCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Camille FangCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Neha ReddyCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Mousa VatanmakanianCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Carolina AltbaumCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Sonia SharmaCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.

Funding

The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)U54AG065141 · NIA · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL, CHENG, SUSAN · 2020 to 2024
$8.7M
Eicosanoids, Chronic Kidney Disease Progression, and Associated Cardiovascular RiskR01DK141162 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Susan Cheng · 2024 to 2026
$3.6M
Training in Immunological MechanismsT32AI125179 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2016 to 2025
$3.1M
NovaSeq5000 High Throughput SequencerS10OD025052 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SEUMOIS, GREGORY · 2018 to 2018
$832k
NIAID NIH HHS T32 AI125179NIA NIH HHS U54 AG065141NIDDK NIH HHS R01 DK141162NIH HHS S10 OD025052
6 · The paper itself

Abstract

Lysophosphatidylcholines (LPCs) are among the most abundant circulating bioactive lipids, whose fatty acid compositions critically influence their immunomodulatory functions. Alterations in circulating LPC species have been implicated in inflammatory settings, including immune checkpoint blockade-associated immune-related adverse events (ICB-irAEs), yet how individual LPC species shape innate immune cell fate remains poorly defined. Here we investigated how unsaturated linoleoyl-LPC (LPC 18:2) and saturated palmitoyl-LPC (LPC 16:0) differentially regulate neutrophil survival and inflammatory responses through distinct cell-intrinsic mechanisms

Indexed as

ApoptosisLysophosphatidylcholinesMembrane MicrodomainsNeutrophilsCaspase 3Cytochromes cExtracellular TrapsHumansMembrane Potential, MitochondrialPeroxidaseReactive Oxygen SpeciesCaspase 3Cytochromes cLysophosphatidylcholinesPeroxidaseReactive Oxygen Speciesapoptosisinflammationlipid raftslysophosphatidylcholine (LPC)NETosisneutrophilsreactive oxygen species (ROS)

Identifiers

PMID42602385
PMCPMC13473843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.