ArticleMultiple sclerosis journal - experimental, translational and clinical
Continuous ofatumumab treatment until the early third trimester in multiple sclerosis with preserved neonatal immunity.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Evidence regarding neonatal immune outcomes following late-gestation exposure to ofatumumab remains limited. We report a 35-year-old woman with relapsing multiple sclerosis who continued ofatumumab until 28 weeks of gestation following individualized shared decision-making based on informed patient preference. The patient remained clinically and radiologically stable throughout pregnancy. Sustained maternal B-cell depletion enabled early postpartum resumption of maintenance therapy without re-induction. Although neonatal immune status at birth was unavailable, her infant showed normal B-cell counts during follow-up and completed routine vaccinations, including live vaccines, without complications. This case provides clinically relevant longitudinal neonatal immune and vaccination data following late-gestation ofatumumab exposure.
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