Evidence map›Paper›PMID 42602307›Full record

ArticleClinical case reports2026

Chronic Pain as an Early Diagnostic Clue in Hereditary Multiple Exostoses: Two Pediatric Cases Highlighting Diagnostic Delay.

Melissa Mariti Fraga, Valesca Oliveira Paes Tanaka, Luciana Tudech Salgueiro Pedro Paulo, Maria Carolina Santos, Carolina Costa Figueiredo, Nara Michelle de Araújo Evangelista, Vânia de Fátima Tonetto Fernandes, Guido de Paula Colares Neto

Abstract read
In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Melissa Mariti FragaDarcy Vargas Children's Hospital São Paulo SP Brazil.ORCID https://orcid.org/0000-0001-5604-1053
Valesca Oliveira Paes TanakaDarcy Vargas Children's Hospital São Paulo SP Brazil.ORCID https://orcid.org/0009-0007-8073-1477
Luciana Tudech Salgueiro Pedro PauloDarcy Vargas Children's Hospital São Paulo SP Brazil.ORCID https://orcid.org/0009-0007-5642-8355
Maria Carolina SantosDarcy Vargas Children's Hospital São Paulo SP Brazil.ORCID https://orcid.org/0000-0002-7958-4269
Carolina Costa FigueiredoDarcy Vargas Children's Hospital São Paulo SP Brazil.ORCID https://orcid.org/0000-0002-1781-3214
Nara Michelle de Araújo EvangelistaDarcy Vargas Children's Hospital São Paulo SP Brazil.ORCID https://orcid.org/0000-0003-2323-3563
Vânia de Fátima Tonetto FernandesCentro Universitário São Camilo, School of Medicine São Paulo SP Brazil.ORCID https://orcid.org/0000-0001-8507-5236
Guido de Paula Colares NetoCentro Universitário São Camilo, School of Medicine São Paulo SP Brazil.ORCID https://orcid.org/0000-0003-3355-0386

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent musculoskeletal pain in children, particularly when associated with palpable masses or a positive family history, should raise suspicion for hereditary multiple exostoses. Recognizing pain as an early diagnostic clue may reduce delay, enabling timely imaging, structured surveillance, and appropriate long-term management.

Indexed as

chronic painhereditary multiple exostosesosteochondromaspediatric musculoskeletal disordersskeletal dysplasia

Identifiers

PMID42602307
PMCPMC13473746

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.