Temporal vision adaptation and restoration in achromatopsia.

Ayelet McKyton, Atira Bick, Deena Elul, Ruth Abulafia, Devora Marks Ohana, Einav Nahmany, Eyal Banin, Netta Levin

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ayelet McKytonfMRI Unit, Department of Neurology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Atira BickfMRI Unit, Department of Neurology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Deena ElulfMRI Unit, Department of Neurology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Ruth AbulafiafMRI Unit, Department of Neurology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Devora Marks OhanaCenter for Retinal and Macular Degenerations (CRMD), Department of Ophthalmology, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Einav NahmanyCenter for Retinal and Macular Degenerations (CRMD), Department of Ophthalmology, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Eyal BaninCenter for Retinal and Macular Degenerations (CRMD), Department of Ophthalmology, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Netta LevinfMRI Unit, Department of Neurology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Temporal vision is stronger under photopic conditions, as cones respond faster than rods, quantifiable via the temporal contrast sensitivity function (tCSF). We examined how the visual system adapts to congenitally slowed input in complete CNGA3/B3 achromatopsia (ACHM), a cone dysfunction forcing lifelong rod reliance, and whether gene therapy restoring cone function improves temporal resolution. Temporal vision was measured in 8 controls, 7 untreated ACHM, and 4 treated ACHM (3 adults and 1 child) under photopic and scotopic conditions, assessing tCSF maximal sensitivity, peak frequency, and flicker fusion frequency (FFF). Controls showed higher values under photopic than scotopic conditions. In untreated ACHM, photopic maximal sensitivity and FFF resembled controls' scotopic values, while peak frequency matched controls' photopic tuning. Among treated ACHM, only the child showed FFF approaching control levels. These findings suggest adaptive peak temporal tuning despite rod-limited resolution and indicate that treatment in childhood may restore temporal resolution.

Indexed as

achromatopsiaadaptationCNGA3CNGB3plasticitytemporal contrast sensitivitytemporal vision

Identifiers

PMID42602306

DOI10.1016/j.isci.2026.117073

PMCPMC13474075

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.