Evidence map›Paper›PMID 42602302›Full record

ArticleiScience2026

Decoding cytarabine-induced damage in the prepubertal testis: A multi-omics atlas of ecosystem and inheritance.

Siyu Xia, Jiangpeng Wu, Jiawei Duan, Wenting Ye, Yan Sun, Xiaojian Yang, Xiao Chen, Hongru Lin, Songyu Huang, Jing Cai and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Siyu XiaCenter for Reproductive Medicine, Dongguan Key Laboratory for Innovative Research on Integrated Traditional Chinese and Western Medicine for the Diagnosis and Treatment of Infertility, Institute of Reproductive Genetics, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province 523000, China.
Jiangpeng WuCenter for Reproductive Medicine, Dongguan Key Laboratory for Innovative Research on Integrated Traditional Chinese and Western Medicine for the Diagnosis and Treatment of Infertility, Institute of Reproductive Genetics, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province 523000, China.
Jiawei DuanCenter for Reproductive Medicine, Dongguan Key Laboratory for Innovative Research on Integrated Traditional Chinese and Western Medicine for the Diagnosis and Treatment of Infertility, Institute of Reproductive Genetics, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province 523000, China.
Wenting YeCenter for Reproductive Medicine, Dongguan Key Laboratory for Innovative Research on Integrated Traditional Chinese and Western Medicine for the Diagnosis and Treatment of Infertility, Institute of Reproductive Genetics, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province 523000, China.
Yan SunCenter for Reproductive Medicine, Dongguan Key Laboratory for Innovative Research on Integrated Traditional Chinese and Western Medicine for the Diagnosis and Treatment of Infertility, Institute of Reproductive Genetics, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province 523000, China.
Xiaojian YangCenter for Reproductive Medicine, Dongguan Key Laboratory for Innovative Research on Integrated Traditional Chinese and Western Medicine for the Diagnosis and Treatment of Infertility, Institute of Reproductive Genetics, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province 523000, China.
Xiao ChenCenter for Reproductive Medicine, Dongguan Key Laboratory for Innovative Research on Integrated Traditional Chinese and Western Medicine for the Diagnosis and Treatment of Infertility, Institute of Reproductive Genetics, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province 523000, China.
Hongru LinCenter for Reproductive Medicine, Dongguan Key Laboratory for Innovative Research on Integrated Traditional Chinese and Western Medicine for the Diagnosis and Treatment of Infertility, Institute of Reproductive Genetics, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province 523000, China.
Songyu HuangCenter for Reproductive Medicine, Dongguan Key Laboratory for Innovative Research on Integrated Traditional Chinese and Western Medicine for the Diagnosis and Treatment of Infertility, Institute of Reproductive Genetics, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province 523000, China.
Jing CaiCenter for Reproductive Medicine, Dongguan Key Laboratory for Innovative Research on Integrated Traditional Chinese and Western Medicine for the Diagnosis and Treatment of Infertility, Institute of Reproductive Genetics, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province 523000, China.
Haiping WenCenter for Reproductive Medicine, Dongguan Key Laboratory for Innovative Research on Integrated Traditional Chinese and Western Medicine for the Diagnosis and Treatment of Infertility, Institute of Reproductive Genetics, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province 523000, China.
Yali SongCenter for Reproductive Medicine, Dongguan Key Laboratory for Innovative Research on Integrated Traditional Chinese and Western Medicine for the Diagnosis and Treatment of Infertility, Institute of Reproductive Genetics, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province 523000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric leukemia therapies can compromise future fertility, particularly in prepubertal boys who cannot bank sperm. We used dose-response histology, endocrine and sperm analyses, bulk and single-cell RNA-seq, and metabolomics to map cytarabine (Ara-C) injury in prepubertal mouse testes. Ara-C caused seminiferous-tubule disruption, hormone suppression, sperm loss, spermatogonial depletion linked to ferroptosis and replication arrest, stress remodeling of Sertoli and Leydig cells, and altered intercellular signaling centered on Sertoli hubs. Unexposed F1 offspring retained inflammatory, nucleotide, and energy-metabolism changes, suggesting intergenerational imprinting after paternal exposure. These findings define cell-type-specific vulnerabilities in the developing testis and nominate redox balance, ferroptosis, Sertoli stress pathways, Leydig inflammatory signaling, and niche communication as targets for fertility-preserving strategies during pediatric chemotherapy.

Indexed as

Cytarabine (Ara-C)Fertility PreservationMulti-OmicsSpermatogonial Stem CellsTesticular Toxicity

Identifiers

PMID42602302
PMCPMC13474082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.