ArticleFrontiers in immunology2026
Ferritin heavy chain 1 expression is correlated with plasma cell exhaustion and acts as a prognostic correlative marker in hepatocellular carcinoma.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Immunotherapy has emerged as a breakthrough in cancer treatment; however, the functional status of B lineage cells within the tumor microenvironment (TME) remains poorly characterized. Objective: This study systematically profiles the heterogeneity and dysfunctional exhausted state of plasma cells in the hepatocellular carcinoma (HCC) TME, and screens molecular signatures correlated with plasma cell exhaustion. Methods: B cell subtypes were identified from a single-cell RNA sequencing (scRNA-seq) dataset comprising 10 untreated patients with primary HCC. Gene expression profiling was performed using transcriptomic data from liver cancer tissues and paired paracancerous tissues. The abundance and distribution of exhausted plasma cells were quantified by immunohistochemistry and multiplex immunofluorescence staining. Furthermore, we analyzed the correlation between plasma cell-specific exhaustion markers and patient prognosis using the TCGA-LIHC cohort. Results: Conclusion: This study systematically profiles the molecular landscape of dysfunctional plasma cells within the HCC TME, confirms a correlation between
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