Evidence map›Paper›PMID 42602243›Full record

ArticleFrontiers in immunology2026

Impact of immune function and white matter integrity on cognitive function in patients with bipolar disorder.

Zhipeng Wang, Tingting Xie, Yumei Wang, Xihua Jia, Xiaobo Wang

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Zhipeng Wang *Department of Ultrasound, the Third Medical Center of Chinese PLA General Hospital, Beijing, China.
Tingting Xie *Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University &Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Yumei WangInstitute of Brain Science and Brain-Inspired Research, Shandong First Medical University &Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Xihua JiaDepartment of Oncology, The First Central Hospital of Baoding, Baoding, Hebei, China.
Xiaobo WangDepartment of Clinical Psychology, The First Central Hospital of Baoding, Baoding, Hebei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cognitive impairment significantly impacts social function in Bipolar disorder (BD). This study explores the link between immune markers, white matter microstructure, and cognitive function in depressed BD patients enhance early diagnosis and treatment. Methods: The study included 52 depressed BD patients and 40 healthy controls(HC), collecting data on inflammation, lymphocyte subpopulations, MRI scans, and cognitive tests, using Spearman correlation and machine learning for comparison. Results: This study found that the CD4+ T cell count ( Conclusion: This study suggests that neuroinflammation and white matter structure play pivotal roles in the pathogenesis of BD with a depressive episode. These findings advance the understanding of the immunological and neuroimaging underlying mechanisms in BD with a depressive episode and highlight potential drivers of cognitive impairment.

Indexed as

Bipolar DisorderCognitionCognitive DysfunctionWhite MatterAdultBiomarkersCytokinesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedBiomarkersCytokinesbipolar disordercognitive functioninflammatory factorslymphocyte subpopulationswhite matter structure

Identifiers

PMID42602243
PMCPMC13473423

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.