Evidence map›Paper›PMID 42602230›Full record

ArticleClinical parkinsonism & related disorders2026

Nocturnal heart rate variability in Parkinson's disease: associations with autonomic dysfunction, cognitive function, and mood symptoms.

Cindy Li, Lina Kleinschmidt, Yatharth Sunkara, Ethan George, Steven M Pogwizd, Adeel A Memon, Amy W Amara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical parkinsonism & related disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cindy LiUniversity of Colorado, Anschutz Medical Campus, Department of Neurology, 13001 E 17th Pl, Aurora, CO, USA 80045.
Lina KleinschmidtUniversity of Colorado, Anschutz Medical Campus, Department of Neurology, 13001 E 17th Pl, Aurora, CO, USA 80045.
Yatharth SunkaraUniversity of Alabama at Birmingham Heersink School of Medicine, 1670 University Blvd, Birmingham, AL, USA 35233.
Ethan GeorgeEmory University School of Medicine, 2015 Uppergate Dr, Atlanta, GA, USA 30307.
Steven M PogwizdUniversity of Alabama at Birmingham Heersink School of Medicine, Department of Medicine, Division of Cardiovascular Disease, 1670 University Blvd, Birmingham, AL, USA 35233.
Adeel A MemonWest Virginia University School of Medicine, Department of Neurology, 64 Medical Center Dr, Morgantown, WV, USA 26506.
Amy W AmaraUniversity of Colorado, Anschutz Medical Campus, Department of Neurology, 13001 E 17th Pl, Aurora, CO, USA 80045.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Heart Rate Variability (HRV) analysis reflects beat-to-beat fluctuations in RR intervals, serving as a method to non-invasively monitor sympatho-vagal balance during sleep. The primary aim of this study is to investigate nocturnal HRV in Parkinson's Disease (PD). In addition, we explore its association with various non-motor symptoms. Methods: In 36 participants with PD and 20 healthy controls (HC), frequency-domain HRV analysis of polysomnography-derived electrocardiogram data was conducted to derive low-frequency power (LF), high-frequency power (HF), and LF/HF ratio in NREM and REM sleep. In PD subjects, Spearman correlations were determined between HRV variables and the MDS-UPDRS sub-scores for autonomic symptoms (1.10-1.12) and mood (1.3, 1.4), the Pittsburgh Sleep Quality Index (PSQI), the Beck Depression Inventory (BDI), and a comprehensive neurocognitive battery. Results: Individuals with PD demonstrated lower LF (NREM Conclusion: Our findings offer novel insight into the association between HRV and non-motor symptoms in PD. Individuals with PD have reduced sympathetic influence on HRV during sleep compared to HC. However, stronger parasympathetic influence correlates with better cognitive performance. Furthermore, subjective autonomic symptoms are correlated with poorer cognition and mood.

Indexed as

Autonomic dysfunctionCognitionHeart rate variabilityMoodParkinson's diseasePolysomnographySleep

Identifiers

PMID42602230
PMCPMC13473945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.