Evidence map›Paper›PMID 42602148›Full record

ReviewFoot & ankle orthopaedics2026

Advancing Prevention and Treatment of Ankle Osteoarthritis: A Translational Clinical Roadmap from the 2026 AOFAS/Arthritis Foundation Ankle Arthritis Think Tank.

Jonathon D Backus, Lew C Schon, William R Ledoux, Mitchell C Coleman, Kelsey H Collins, Scott J Ellis, Amy L Lenz, Cesar de Cesar Netto, Constantine A Demetracopoulos, Nancy E Lane and 10 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Foot & ankle orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jonathon D BackusSteadman Clinic and Steadman Philippon Research Institute, Vail, CO, USA.ORCID https://orcid.org/0000-0003-2426-170X
Lew C SchonInstitute for Foot and Ankle Reconstruction at Mercy Medical Center, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-9778-3598
William R LedouxRR&D Center for Limb Loss and MoBility (CLiMB), VA Puget Sound Health Care System, Seattle, WA, USA.ORCID https://orcid.org/0000-0003-4982-7714
Mitchell C ColemanDepartment of Orthopedics and Rehabilitation, University of Iowa, Iowa City, IA, USA.
Kelsey H CollinsDepartment of Orthopaedic Surgery and Anatomy, University of California San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0001-7348-7348
Scott J EllisHospital for Special Surgery, New York City, NY, USA.ORCID https://orcid.org/0000-0002-4304-7445
Amy L LenzDepartment of Mechanical Engineering, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0003-2998-0906
Cesar de Cesar NettoDepartment of Orthopaedic Surgery, Duke University, Durham, NC, USA.ORCID https://orcid.org/0000-0001-6037-0685
Constantine A DemetracopoulosHospital for Special Surgery, New York City, NY, USA.
Nancy E LaneDepartment of Medicine, University of California at Davis, Sacramento, CA, USA.
Jason M WilkenDepartment of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA.
Annunziato AmendolaDepartment of Orthopaedic Surgery, Duke University, Durham, NC, USA.
Anish R KadakiaDepartment of Orthopaedic Surgery, Northwestern University, Chicago, IL, USA.
Erik A WikstromDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kenneth J HuntDepartment of Orthopaedic Surgery, University of Colorado, Aurora, CO, USA.ORCID https://orcid.org/0000-0002-8369-8744
Bopha ChreaDepartment of Orthopedics and Rehabilitation, University of Iowa, Iowa City, IA, USA.ORCID https://orcid.org/0000-0003-4328-9855
Judith F BaumhauerDepartment of Orthopaedics, University of Rochester, Rochester, NY, USA.ORCID https://orcid.org/0000-0003-2142-7778
Todd O McKinleyDepartment of Orthopaedic Surgery, Indiana University, Indianapolis, IN, USA.
Michelle McLeodThe Arthritis Foundation, Atlanta, GA, USA.
Donald D AndersonDepartment of Orthopedics and Rehabilitation, University of Iowa, Iowa City, IA, USA.ORCID https://orcid.org/0000-0002-1640-6107

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ankle osteoarthritis (OA) is predominantly post-traumatic in origin. It differs in important ways biologically, mechanically, and clinically from hip and knee OA. Despite recognition of its long-term burden, treatment strategies for ankle OA remain largely reactive and centered on end-stage reconstruction. The Arthritis Foundation and the American Orthopaedic Foot & Ankle Society (AOFAS) co-sponsored an Ankle Arthritis Think Tank to address this deficiency in Napa, CA, on January 22, 2026. The focus was to solve patient frustration of limited treatment options and relatively poor outcomes when comparing to hip and knee osteoarthritis. The 2026 meeting brought together a multidisciplinary group of scientists and clinicians to present our current related state of knowledge and to define translational research priorities capable of advancing prevention and treatment of ankle OA within the next decade. Four structured sessions addressed topics relating to ankle OA: (1) Biologic and Biomechanical Pathogenesis, (2) Diagnostic and Management Challenges, (3) Therapeutic Strategies, and (4) Research Methodology. A moderated closing discussion focused on identifying actionable and fundable research pathways. Session presentations and discussion are synthesized here into a unified review.

Indexed as

ankle osteoarthritisarthritistranslational roadmap

Identifiers

PMID42602148
PMCPMC13473791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.