ArticleMultiple sclerosis journal - experimental, translational and clinical
Patterns and predictors of transition between multiple sclerosis phenotypes: A longitudinal analysis.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Multiple sclerosis (MS) phenotype transitions are challenging to characterize. Our understanding of their predictors is also limited. Objective: To investigate the transition between relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) within the Comprehensive Longitudinal Investigation of MS at the Brigham and Women's Hospital (CLIMB) study. Methods: This retrospective study included adult people with MS having ≥10-year follow-up data who were classified as RRMS, primary progressive MS, and SPMS (active SPMS [aSPMS]: with relapse; nonrelapsing SPMS [nrSPMS]: no relapses within 2-year pre-index). Demographics, disability scores, and transition predictors were assessed. Results: Ninety-seven of 565 people with RRMS (17.2%) transitioned to SPMS, of whom 92.8% ( Conclusion: This study provides a comprehensive characterization of MS phenotype transitions, that may enhance clinical decision-making and therapeutic targeting of underlying pathophysiology driving disability in progressive MS.
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