ArticleFrontiers in aging2026
Preliminary assessment of sarcopenic obesity risk after sleeve gastrectomy using dual-modality imaging: a six-month MRI and DXA pilot study in women.
Article in Frontiers in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04617392 (Research of Sarcopenia in Patients After Bariatric-metabolic Surgery - the Effect of Programmed Aerobic and Power Exercising on the Functionality, Volume and Morphology of Muscle Tissue), which is not on this map. Not yet cited in PubMed.
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Research of Sarcopenia in Patients After Bariatric-metabolic Surgery - the Effect of Programmed Aerobic and Power Exercising on the Functionality, Volume and Morphology of Muscle Tissue
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Abstract
Introduction: Sarcopenic obesity (SO) is characterized by excess adiposity combined with skeletal muscle loss, but the absence of standardized diagnostic criteria makes interpretation of muscle tissue changes after bariatric surgery difficult, and different diagnostic indices can yield markedly different conclusions about the same patients. Methods: This preliminary analysis from the SarxOb trial (NCT04617392) compared several body-composition indices for detecting SO risk in eleven female patients undergoing laparoscopic sleeve gastrectomy, prospectively followed for six months using dual-modality imaging - magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry (DXA). Results: Lean body mass (LBM) decreased significantly from 56.3 ± 6.2 kg to 47.6 ± 6.0 kg (p < 0.001), while LBM as a percentage of total body weight increased from 50.4 ± 3.2% to 57.9 ± 4.3% (p = 0.003), reflecting a disproportionately greater loss of fat mass than lean mass. Appendicular skeletal muscle mass (ASM) decreased from 24.5 ± 3.3 kg to 20.1 ± 2.9 kg (p < 0.001). Critically, the choice of diagnostic index changed the apparent prevalence of SO risk entirely: by the ASM and ASM/height Conclusion: These results indicate that weight-adjusted indices detect a substantially higher burden of SO risk than traditional height-adjusted indices in this population, and that the choice of diagnostic index, not only the imaging modality used, is a major source of disagreement in reported SO risk prevalence after bariatric surgery. Given the small sample size inherent to this interim analysis of an ongoing trial, these findings should be considered exploratory and hypothesis-generating rather than confirmatory. As functional muscle assessment was not available in this interim report, these findings should be interpreted as SO risk by body-composition criteria rather than a complete EWGSOP2/ESPEN-EASO diagnosis.
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