ArticleFrontiers in psychology2026
Association of asthma control, treatment, adherence, lung function, and allergy sensitization with depressive symptoms and quality of life in a real-life setting.
Article in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Asthma is a chronic inflammatory respiratory disease that is frequently associated with emotional distress and impaired quality of life. However, how clinical factors, such as treatment, adherence, lung function, and allergy sensitization, relate to depressive symptoms remains unclear. In this study, we examined the associations among asthma control, treatment, adherence, lung function, allergy sensitization, somatic and cognitive-affective depressive symptoms, and quality of life in a real-life clinical setting. Methods: This cross-sectional study included adults with asthma attending tertiary pneumology and allergy services, and their asthma symptoms were evaluated using the standardized measures of the Asthma Control Test, GINA 2022 (treatment), Test of Adherence to Inhalers, lung function, skin prick test for allergy sensitization, PHQ-9 (depressive symptoms), Asthma Quality of Life Questionnaire, serum eosinophils and IgE levels. Results: Of 102 asthma patients, 51% of participants scored more than 5 points on the PHQ-9, indicating the presence of depression. Poor asthma control and lower adherence scores were significantly associated with higher depressive symptoms ( Conclusion: Emotional distress and quality of life are more strongly related to patients' perceived control of their disease and adherence behaviors than to objective physiological markers. Thus, psychological and self-management strategies should be integrated into routine asthma care.
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