ArticleFrontiers in cell and developmental biology2026
PLIN1a: the principal protein isoform that performs the function of chicken PLIN1.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Advances in Poultry RNA-Omics Research: Technologies, RNA Information Layers, and Applications in Complex Traits.Animals : an open access journal from MDPI · 2026Review
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15 authors.
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Abstract
PLIN1 is the predominant structural and regulatory protein associated with lipid droplets (LDs) in avian species and plays an essential role in lipid metabolism. The NCBI RefSeq database currently annotates 10 transcripts at the chicken PLIN1 locus; however, only one transcript has been verified experimentally, while the remaining nine are computational predictions. In this study, we identified five distinct transcript variants encoding four N-terminally divergent protein isoforms of chicken PLIN1 using RNA ligase-mediated rapid amplification of cDNA ends (RLM-RACE). Immunolocalization assays showed that all PLIN1 isoforms were targeted to the surface of LDs during preadipocyte differentiation. Functional analyses revealed that PLIN1 isoforms play evolutionarily conserved roles in inhibiting cell proliferation, promoting adipogenic differentiation, and facilitating Fsp27-mediated formation of supersized lipid droplets. Among all isoforms, PLIN1a exhibited the strongest regulatory effects in all functional assays. These findings clarify the transcript diversity and functional differentiation of avian PLIN1, provide new insights into the structural basis of LD regulation, and contribute to a better understanding of lipid storage and metabolic adaptation in vertebrates.
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