ArticleFrontiers in immunology2026
Identification of novel HLA class I-restricted hepatitis B virus peptides and their modulation by peptide editor TAPBPR.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma and infections remain a substantial global health problem for which no curative therapy exists. As cytotoxic CD8 Methods: To discover new HBV-derived peptides, immunopeptidomic analysis was performed on cells expressing single HLA class I molecules transduced to express individual HBV proteins. Peptide binding assays were used to validate HLA binding of selected peptides. Additionally, we used immunopeptidomic analysis to determine the effect of the recently discovered major histocompatibility complex class I (MHC-I) peptide editor TAPBPR on presentation of HBV-derived peptides. The results were validated using TAPBPR peptide-exchange assays. Results: We identified 28 novel HBV-derived peptides presented on HLA class I. Importantly, 22 of the newly discovered HBV-derived peptides were identified on cells expressing HLA-B*08:01, -B*15:03, -B*35:01, -C*06:02 and -C*12:03. Discussion: This work presents a substantial expansion of the HLA-B and HLA-C-restricted HBV-derived peptides described in the Immune Epitope Database (IEDB). Additionally, TAPBPR
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