Evidence map›Paper›PMID 42601949›Full record

ArticleFrontiers in endocrinology2026

Diverging pathomechanisms underlying collagen I-related and MBTPS2-related osteogenesis imperfecta: insights from patient-derived fibroblasts and iPSC-based modelling of bone.

Pei Jin Lim, Giulio Marcionelli, Ceres Blättler, Silvan Gut, Marianne Rohrbach, Cecilia Giunta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pei Jin LimConnective Tissue Unit, Division of Metabolism and Children's Research Centre, University Children's Hospital Zurich and University of Zurich, Zurich, Switzerland.
Giulio MarcionelliConnective Tissue Unit, Division of Metabolism and Children's Research Centre, University Children's Hospital Zurich and University of Zurich, Zurich, Switzerland.
Ceres BlättlerConnective Tissue Unit, Division of Metabolism and Children's Research Centre, University Children's Hospital Zurich and University of Zurich, Zurich, Switzerland.
Silvan GutConnective Tissue Unit, Division of Metabolism and Children's Research Centre, University Children's Hospital Zurich and University of Zurich, Zurich, Switzerland.
Marianne RohrbachConnective Tissue Unit, Division of Metabolism and Children's Research Centre, University Children's Hospital Zurich and University of Zurich, Zurich, Switzerland.
Cecilia GiuntaConnective Tissue Unit, Division of Metabolism and Children's Research Centre, University Children's Hospital Zurich and University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteogenesis imperfecta (OI), characterised by low bone mass and bone fragility, is a heritable disorder with a heterogeneous genetic cause. Type I collagen is the most predominant type of collagen in the bone. Hence, the vast majority of patients with OI carry genetic variants in the genes that encode for type I collagen. However, a fraction of patients have defects in genes that either participate in collagen synthesis and maturation, in osteoblast maturation and functions including bone mineralisation, or with yet fully-understood mechanisms. An intriguing example is

Indexed as

Bone and BonesCollagen Type IFibroblastsInduced Pluripotent Stem CellsOsteogenesis ImperfectaCell DifferentiationCells, CulturedHumansOsteoblastsCollagen Type ICOL1-OIcollagen qualityinduced pluripotent stem cellMBTPS2-OIosteogenesis imperfecta (OI)

Identifiers

PMID42601949
PMCPMC13472802

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.