ArticleFrontiers in physiology2026
Placental SNV rs8192446 in the
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Preeclampsia (PE) is one of the leading causes of maternal and fetal morbidity and mortality worldwide. An impaired trophoblast invasiveness and resulting defective remodeling of spiral arteries lead to placental hypoxia that promotes the release of different antiangiogenic and proinflammatory factors to maternal circulation. Adenosine a purine nucleoside derived from ATP metabolism, is among these factors, and high concentrations have been observed in the sera of women affected with PE. The raise in adenosine levels is linked to elevated placental expression of the adenosine A2A receptor (ADORA2A), yet the contribution of single-nucleotide variations (SNVs) in the Methods: Five SNVs (rs2298383, rs4822489, rs2236624, rs17650937, and s8192446) were genotyped using real-time PCR with TaqMan probes. The functional effect of the N144K mutation was evaluated through Results: The SNV rs8192446 was strongly associated with PE [OR=10.42 (95% CI: 2.08-103.39, p=0.0009)], association that remained after BH correction (p=0.0009). The SNV rs8192446 was also associated with mild PE (p=0.0403) and severe PE (p=0.0072). Discussion: Taken together, these results suggest that placental
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