ArticleFrontiers in medicine2026
Association between tranexamic acid and postoperative delirium in elderly patients: a mediation analysis of inflammatory markers following hip and knee arthroplasty.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postoperative delirium (POD) is a common complication in elderly patients undergoing hip or knee arthroplasty, and neuroinflammation plays a critical role in its pathogenesis. In addition to its antifibrinolytic properties, tranexamic acid (TXA) also exhibits anti-inflammatory effects. However, whether there is an association among TXA, inflammation, and POD remains poorly investigated. Therefore, this study aimed to investigate the effect of intravenous TXA on the incidence of POD in elderly patients undergoing hip or knee arthroplasty and to analyze the potential mediating role of inflammatory markers. Methods: This single-center, retrospective cohort study included 1,234 elderly patients (aged ≥65 years) undergoing hip or knee arthroplasty at our institution between January 2017 and January 2026. Patients were divided into the TXA group ( Results: The incidence of POD was significantly lower in the TXA group than in the control group (26.0% vs. 41.9%, Conclusion: Intravenous TXA administration is significantly associated with a reduced incidence of POD in elderly patients undergoing hip or knee arthroplasty. This association may be partially mediated by inflammatory markers, including NLR, SIRI, SII, hs-CRP, and IL-6. These findings contribute to the development of more effective strategies to improve the quality of postoperative recovery in elderly patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.