ArticleFrontiers in medicine2026
Clinical characteristics and associated factors of cardiovascular involvement in patients with relapsing polychondritis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: To analyze the clinical characteristics and identify factors associated with cardiovascular involvement in patients with relapsing polychondritis (RP). Methods: A total of 105 RP patients were enrolled and divided into cardiac and non-cardiac groups. Demographic, clinical, and serological data were collected and analyzed comparatively. Univariate and Firth's logistic regression analyses were performed to identify independent factors associated with cardiac involvement. Hierarchical clustering was applied to explore phenotypic patterns. Results: Among the RP cohort, 29.5% (31/105) exhibited cardiovascular involvement, with a male-to-female ratio of 16:15 and a mean age of 57.87 ± 12.06 years. Manifestations included aortic root dilatation (11.4%), conduction abnormalities (8.6%), myocarditis (7.6%), pericarditis (5.7%), and valvular dysfunction (3.8%). Patients with cardiac involvement exhibited a significantly lower prevalence of ocular involvement (12.9 vs. 36.5%; Conclusions: Cardiac involvement in RP is not rare and is independently associated with lower LDL levels and reduced frequencies of ocular and costal cartilage involvement. These findings may help identify RP patients at risk for cardiac manifestations and suggest potential protective roles of certain clinical features.
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