Trial reportFrontiers in nutrition2026
Dietary α-linolenic acid improves skin blood flow following cold exposure and endothelial function in healthy adults: a randomized, double-blind, placebo-controlled, parallel-group comparative trial.
Trial report in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
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Abstract
Introduction: Previous studies have suggested that α-linolenic acid (ALA) improves vascular function and alleviates allergic symptoms. However, its effects on cold sensitivity, associated with peripheral vascular function, remain poorly understood. Furthermore, no studies have reported ALA's efficacy alone in healthy humans regarding vascular endothelial function or allergic symptoms. This study aimed to clarify ALA intake effects on cold sensitivity, vascular endothelial function, and ocular/nasal allergy symptoms in healthy individuals. Methods: This randomized, double-blind, placebo-controlled, parallel-group trial enrolled 120 healthy Japanese adults experiencing cold sensitivity. Subjects consumed edible oils with different ALA contents (1.27 g or 2.03 g/day) or placebo for 12 weeks. Cold sensitivity (blood flow and skin temperature after cold exposure), vascular endothelial function, and allergy symptoms were measured. Results: Skin blood flow and skin surface temperature showed significantly higher values or trends toward higher values in ALA groups during early measurement period following cold exposure ( Conclusion: ALA intake increased serum n-3 fatty acids and showed beneficial effects on cold sensitivity and endothelial function in Japanese adults without overt diseases. Clinical trial registration: [https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000066500], identifier [UMIN000058298].
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